Antibody drug conjugates in blue setting

Case studies

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Molecule
Mode
Application
laboratory equipment closeup, bottles of acetone and isopropanol
  • Model development
  • Scale-up
  • |
  • IEX
  • |
  • Antibody

Mechanistic identification of CEX elution conditions for an antibody aggregate separation using Kp screening

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Human pathogenic virus
  • Manufacturability
  • Model development
  • Process development
  • |
  • IEX
  • |
  • VLP

Speeding up VLP purification process development

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Model derivation, a protein approaches the adsorber surface_Casestudy Modeling of ion exchange chromatography
  • Model development
  • |
  • IEX
  • |
  • Antibody
  • Other protein

Modeling of ion exchange chromatography: From mechanistic to empirical and back

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MD visualization of water and salt molecules around a protein_Casestudy HIC
  • Model development
  • |
  • HIC
  • |
  • Antibody
  • Other protein

Extension of a mechanistic HIC model to account for pH changes and mixed-mode binding

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Scientist working with an Äkta
  • Scale-up
  • |
  • IEX
  • |
  • Antibody

In silico scale-up and scale-down: suitable for high-load IEX

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Monoclonal antibody
  • Manufacturability
  • Optimization
  • Process development
  • |
  • IEX
  • |
  • Antibody

Optimization of an antibody polishing step

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laboratory equipment close up bottles with prepared liquids
  • Model development
  • |
  • IEX
  • |
  • Antibody

Modeling of complex protein elution behavior

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SEM picture of PA6 winged fiber in the case study Model development for polymer fibers as stationary phases
  • Model development
  • |
  • IEX
  • |
  • Other protein

Model development for polymer fibers as stationary phases

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laboratory equipment close up, bottles and machine
  • Model development
  • |
  • HIC
  • |
  • Other protein

Model development for hydrophobic interaction chromatography

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Bioprocess characterization - gain in silico insights in your process.
  • PCPV
  • Trouble shooting
  • |
  • IEX
  • |
  • Other protein

Process characterization for troubleshooting

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laboratory equipment close up
  • Model development
  • PCPV
  • Scale-up
  • |
  • IEX
  • |
  • Other protein

Adsorber quantification in batch and column chromatography

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Virus-like particle in blue setting
  • Model development
  • Process development
  • |
  • IEX
  • |
  • VLP

Model-based process development for virus-like particles

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